
Signature
Billy
Bush, Cheney & Pelosi, Behind Bars
http://rachelcorriefoundation.org/site/
http://en.wikipedia.org/wiki/Movement_to_impeach_George_W._Bush
In article
<wildbilly-14C593.09470428022008@c-61-68-245-199.per.connect.net.au>,
> > When you learn the art of gardening, there are few safety considerations
> > that you need to address. No matter what type of gardening project you
[quoted text clipped - 41 lines]
> beginning gardeners when they (the advice, not the gardeners) become
> seasonally applicable.
I'm more concerned that Rotenone and Parkinson Disease may have a
connection. May? Friends dad had Parkinson¹s and used Rotenone
commercially. Organic pesticide may be a misnomer lulling us to be
careless. Thinks that kill may be just that. Fishing with Rotenone was
a S. American technique for fishing. Guess it is less violent then
dynamite.
Bill
........................
: J Pineal Res. 2008 Mar;44(2):205-13.
Links
Melatonin reduces the neuronal loss, downregulation of dopamine
transporter, and upregulation of D2 receptor in rotenone-induced
parkinsonian rats.
Lin CH, Huang JY, Ching CH, Chuang JI.
Department of Physiology, College of Medicine, National Cheng Kung
University, Tainan, Taiwan.
Parkinson's disease (PD) is a movement disorder resulting from
nigrostriatal dopaminergic neurodegeneration. The impairment of
mitochondrial function and dopamine synaptic transmission are involved
in the pathogenesis of PD. Two mitochondrial inhibitors,
1-methyl-4-phenylpyridine (MPP(+)) and rotenone, have been used to
induce dopaminergic neuronal death both in in vitro and in vivo models
of PD. Because the uptake of MPP(+) is mediated by the dopamine
transporter (DAT), we used a cell-permeable rotenone-induced PD model to
investigate the role of DAT and dopamine D2 receptor (D2R) on
dopaminergic neuronal loss. Rotenone subcutaneously infused for 14 days
induced PD symptoms in rats, as indicated by reduced spontaneous
locomotor activity (hypokinesis), loss of tyrosine hydroxylase (TH, a
marker enzyme for dopamine neurons) immunoreactivity in the substantia
nigra and striatum, obvious alpha-synuclein accumulation, downregulated
DAT protein expression, and upregulated D2R expression. Interestingly,
rotenone also caused significant noradrenergic neuronal loss in the
locus coeruleus. Melatonin, an antioxidant, prevented nigrostriatal
neurodegeneration and alpha-synuclein aggregation without affecting the
rotenone-induced weight loss and hypokinesis. However, rotenone-induced
hypokinesis was markedly reversed by the DAT antagonist nomifensine and
body weight loss was attenuated by the D2R antagonist sulpiride. In
addition, both antagonists significantly prevented the reduction of
striatal TH or DAT immunoreactivity but not the loss of nigral TH- and
DAT-immunopositive neurons. These results suggested that oxidative
stress and DAT downregulation are involved in the rotenone-induced
pathogenesis of nigrostriatal dopaminergic neurodegeneration, whereas
D2R upregulation may simply represent a compensatory response.
PMID: 18289173 [PubMed - in process]

Signature
Garden in shade zone 5 S Jersey USA
ICAO = KMIV Millville Weather
Lat 39.5982 Long -75.0358
Billy - 28 Feb 2008 19:55 GMT
In article
<b2forewagner-29E5C5.13153828022008@sn-indi.vsrv-sjc.supernews.net>,
> In article
> <wildbilly-14C593.09470428022008@c-61-68-245-199.per.connect.net.au>,
[quoted text clipped - 92 lines]
> D2R upregulation may simply represent a compensatory response.
> PMID: 18289173 [PubMed - in process]
The pain of not knowing touches more people than those immediately
affected.
Many researchers believe that several factors combined are involved:
free radicals, accelerated aging, environmental toxins, and genetic
predisposition. Two of these should be controllable: free radicals and
environmental toxins.
Free radical can be controlled with anti-oxidants found in fresh fruits
and vegetables.
Toxicity, however, isn't always as obvious as what happened in Bhopal,
India. When guinea pigs (human or otherwise) don't immediately drop
stone cold dead after they are administered a drug (re: chemical), there
is always marketing wiggle room. The rise in cardiovascular disease,
diabetes, chronic fatigue, cancer, autism, SIDS and a host of other
plagues have no obvious reason. What we do know is that industrial
chemicals, errant pharmaceuticals, and pesticide residues have invaded
our environment since the end of WWII. The chemicals come on and in our
food (sometimes added, sometimes contaminated), our drinking water
(agricultural run off, industrial dumping, pharmaceuticals that survive
treatment plants that find their way back into our drinking water), and
in the air (especially around refineries and smoke stacks). The worry is
amplified by magnitudes when presumed quantities of a single chemical
are reassuringly, exceedingly small, but no one knows the risks of
synergistic interactions between multiple chemicals and our bodies,
especially young developing bodies.
What most facilitates these chemicals into our bodies?
Lobbyi$t$.

Signature
Billy
Bush, Cheney & Pelosi, Behind Bars
http://rachelcorriefoundation.org/site/
http://en.wikipedia.org/wiki/Movement_to_impeach_George_W._Bush